About SUPRELORIN® F (deslorelin acetate) Implant

Help ferrets pursue a healthier life.

Short of complete removal of both adrenal glands from a ferret with adrenal disease, which can be a risky procedure, there is no true cure for the condition. But now that the SUPRELORIN® F Implant is available in the US, ferret owners, like you, have a simple, convenient, medical alternative for controlling the clinical signs of the disease in your pet ferret.

Real-world experience

SUPRELORIN F Implant has been demonstrated effective.1–3

Results from published studies have shown that the most common signs of adrenal disease are all reduced quickly after implantation with SUPRELORIN F Implant and resolve for up to 1 year.1–4 Studies demonstrated that the 4.7 mg deslorelin acetate implant was effective.1–4

Health benefits with SUPRELORIN F Implant

Use of 4.7 mg SUPRELORIN F Implant was also shown to dramatically suppress key hormones (estradiol, hydroxyprogesterone, and androstenedione) within the treatment period.2 And that’s good news for you and your ferret. The result is a healthier ferret. Now there’s an option that could save your beloved ferret from suffering the effects of adrenal disease or the frequent visits to the veterinarian to receive injections.


SUPRELORIN F Implant has been shown to be safe for use in ferrets .1–3

In the US, SUPRELORIN F Implant is available as an implant containing 4.7 mg of deslorelin acetate. Published studies have found the SUPRELORIN F Implant safe for use in ferrets with appropriate clinical monitoring. It is possible that treated ferrets will show some soreness and swelling at the implantation site, which should resolve over 1 to 2 weeks.3 Other reported side effects include: weight gain, lethargy, and failure to respond to therapy. Blood tests were shown to be within the normal range after treatment.2 This safety profile, coupled with the effectiveness of SUPRELORIN F Implant, should offer you peace of mind.

Dosing and Administration

The SUPRELORIN F Implant is easy for veterinarians to implant—and requires a single implant. Appropriate endocrine testing and clinical monitoring should be used to assess your ferret’s response to therapy. Your veterinarian will likely schedule follow-up visits after implantation.

Convenience: One implant is inserted subcutaneously (under the skin) between the shoulder blades of the ferret. In the majority of reports, the treatment lasted 12 months.1 As implant efficacy declines, the implant itself dissolves, requiring no removal.

Importance of reimplantation: Because medical therapies are not cures, a relapse of clinical signs is likely once the effects of the SUPRELORIN F Implant wear off. The timing of reimplantation will be based on your ferret’s individual health status and when clinical signs begin to return and should be determined by your veterinarian.

If you are a veterinarian seeking further information on the effectiveness, safety, and administration of SUPRELORIN F Implant…

NOT APPROVED BY FDA—Legally marketed as an FDA Indexed Product under MIF 900-013. FOR USE IN FERRETS ONLY. Extra-label use is prohibited. This product must not be used in animals intended for use as food for humans or other animals.

Important safety information

For use in ferrets only. Do not use in animals intended for breeding. The safe use of this product has not been evaluated in pregnant or lactating ferrets. Do not use this product in ferrets with known hypersensitivity to deslorelin acetate or other synthetic hormones. DO NOT HANDLE THIS PRODUCT IF YOU ARE PREGNANT OR NURSING OR SUSPECT YOU MAY BE PREGNANT. Accidental administration may lead to a disruption of the menstrual cycle. Refer to the package insert for complete product information.


  1. Literature on file, Virbac Animal Health.
  2. Wagner RA, Piché CA, Jöchle W, Oliver JW. Clinical and endocrine responses to treatment with deslorelin acetate implants in ferrets with adrenocortical disease. Am J Vet Res. 2005;66(5):910–914.
  3. Shoemaker NJ. Everything you wanted to know about adrenal disease in ferrets. In: Proceeding of the North American Veterinary Conference (NAVC); January 19–23, 2008; Orlando, FL. Available at: http://www.ivis.org/docarchive/proceedings/navc/2008/sae/675.pdf. Accessed October 17, 2011.
  4. Wagner RA, Finkler MR, Fecteau KA, Trigg TE. The treatment of adrenocortical disease in ferrets with 4.7 mg deslorelin acetate implants. J Exotic Pet Med. 2009;18(2):146–152.